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Light Microscopy Center
The Light Microscopy (LM) Center has been active since 2007. It offers access to both standard and innovative advanced light microscopy infrastructure and applications including technical operator assistance, assistance in image analysis and in-depth microscopic imaging knowledge.Our experts
News, events and publications
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New state-of-the-art transmission electron microscope (TEM) at Radboudumcinstalled and in operation10 July 2023
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Large AI project receives over €95 million for ten years of public-private research23 September 2021
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New start-up Patholyt will bring AI research into pathology diagnostics21 September 2021
RTC Microscopy seminars
Experts and users of the RTC Microscopy present seminars on various microscopy setups and their applications.
read moreRTC Microscopy seminars
Experts and users of the RTC Microscopy present seminars on various microscopy setups and their applications.
For each edition of the RTC Microscopy Seminars, we aim to include one seminar on electron microscopy, one on light microscopy, and one on image analysis. The seminars target a broad audience and besides presenting the results of a microscopy-based research project, the presenters typically also provide a basic overview of the possibilities and pitfalls of the used techniques. The next RTC Microscopy Seminars will be announced soon. The past events can be found below.
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Program
- Luco Rutten (Medical Biosciences): The power of transmission electron microscopy: from basic to advanced TEM at Radboudumc
- Malou Zuidscherwoude (Medical Biosciences): Advanced light microscopy approaches to understand the interaction between the calcium channel TRPV5 and calmodulin
- Gert-Jan Bakker (Medical Biosciences): QUAREP-LiMi, a community-driven initiative for improved reproducibility in microscopy related research
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Program
- Robin van der Meijden (Medical Biosciences): 3D correlative live-to-cryo imaging: combining Raman, light and electron microscopy on Biological Tissues
- Mark Gorris (Medical Biosciences): Studying Immune Cells in the Tumor Microenvironment: Multiplex Immunohistochemistry and Multispectral Imaging
- Sjoerd van Deventer (Medical Biosciences): Combining dSTORM and cluster analysis to investigate the plasma membrane nanoscale organization
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Program
- Julie Verhoef (Medical Microbiology): (Cryo-)Expansion microscopy to visualize malaria parasites
- Marcos Eufrásio Cruz (Biochemistry): Understanding the functionality of extracellular matrix vehicles using cryogenic transmission electron microscopy
- Andrea Frielink-Loing (RTC Data Stewardship): Digital Research Environment for data storage, analysis, and collaboration
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Program
- Moritz Negwer (Human Genetics/Donders Center): Tissue clearing and light-sheet microscopy: whole-organ imaging at cellular resolution
- Mariska Kea-te Lindert (Electron Microscopy Center, RTC Microscopy): 3D array tomography: an accessible method for 3D imaging of millimeter volumes at nanoscale resolution
- Merijn van Erp (RTC Microscopy): Deep learning for the selective segmentation of cellular structures
Published papers
2022
- SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids (Jansen et al., 2022)
- Intravital deep-tumor single-beam 3-photon, 4-photon, and harmonic microscopy (Bakker et al., 2022)
- Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis (Boekhorst et al, 2022)
2021
- Genetic hybridization of highly active exogenous functional proteins into silk-based materials using 'light-clothing' strategy (Long et al., 2021)
- Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity (Weigelin et al., 2021)
- Tutorial: methods for three-dimensional visualization of archival tissue material (Haddad et al, 2021)
