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Research Research programs Sanity:

Our purpose

We aim to understand how distinct ablation treatments can best be combined with different immunotherapy approaches.

Goals

See some of the most important goals for this research program.

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Goals

In SANITY, key scientific aims are to understand: 

  • how distinct ablation treatments can best be combined with different immunotherapy approaches.
  • the impact of the tumor microenvironment (TME: hypoxia, metabolism, glycosylation, composition) on treatment efficacy.
  • which immune pathways are responsible for therapy success or failure.
  • how to select the best combination therapy for the individual patient.
  • how to develop a route for responsible and sustainable clinical adoption of immunotherapy treatment and tumor ablation.


Research groups contributing to this research program

Biological and molecular imaging in experimental radiotherapy

Jan Bussink's research group aims to 'reprogram' the metabolism of tumors, giving the immune system more 'grip' on tumor cells and making tumor cells more sensitive to radiotherapy.

Early health technology assessment

Janneke Grutters's research group develops and applies methodology to evaluate the (potential) value of innovations in healthcare, as of an early stage of development.

Molecular prognostic and predictive factors in solid tumors

Paul Span's research group focuses on several mechanisms of radioresistance such as hypoxia, autophagy, metabolism, and genomic instability (APOBEC).

Spokesperson(s) for this research program

Spokesperson

prof. dr. Gosse Adema

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