dr. Rick Greupink

Over Rick Greupink

Dr. Rick Greupink obtained a MSc in pharmaceutical sciences and was trained as a pharmacist (PharmD) at the University of Groningen. He obtained a PhD in Pharmacokinetics and Drug Delivery from the same university and further specialized as a pharmacologist during postdoctoral fellowships in both clinical as well as pre-clinical settings in pharmaceutical industry and academia. He is a registered pharmacologist with the Dutch Pharmacological Society and served on the board of the Society. He lectures in pharmacology and pharmacotherapy at Radboud University Medical Center and Radboud University. At Radboud University Medical Center, Rick was commended with the status of associate Principle Lecturer and he was an active member of the Program Committee for the Biomedical Sciences curriculum (Opleidingscommissie-BMW). Currently, Rick is chair of the project group that develops the Biomedical Sciences Master track: Development of Advanced Medicines and Drug Repurposing. Rick is member of staff of the Department of Pharmacy, Pharmacology and Toxicology, where his research focuses on translational pharmacology, in particular the in vitro-to-in vivo extrapolation (IVIVE) of drug disposition and drug-induced toxicity. By combining in vitro molecular pharmacology studies in human tissues and cells with in silico modeling, he aims to develop a better understanding of how drugs behave in the body, predict clinical pharmacokinetics and anticipate therapeutic and off-target effects. Next to improving our understanding of the pharmacological mechanisms driving clinical effects, the approach also aids in guiding drug and dose selection in special patient populations and allows pharmacological characterization of molecules still in the early phases of drug discovery. In his work, Rick combines in vitro molecular laboratory studies with physiology-based pharmacokinetic (PBPK) modeling to predict systemic and tissue exposure, as well as pharmacophore modeling approaches to study and predict target binding. Current projects center around the placental disposition and molecular effects of small and large molecule pharmaceuticals, in relation to maternal, fetal and perinatal pharmacokinetics and drug safety. 

Nevenfuncties

• Expert network member European Medicines Evaluation Board
• Member of the Education Committee of the Dutch Pharmacological Society
• Chair of the working group for developement of the new Biomedical Sciences MSc track: "Development of advanced Medicines & Drug Repurposing"
• Course Coordinator BMS63 - Biodynamic and Toxicokinetic Modeling (graduate program biomedical sciences, drug safety and toxicology specialization)
• Course Coordinator MOL53 (FNWI): Medicinal Chemistry
• Vice coordinator of the elective Master course Organ Toxicology in Drug Safety, Master Biomedical Sciences
• Secretary General & Treasurer of the Dutch Pharmacological Society (2019-2023)
• Member of the Program Committee for Biomedical Sciences (Opleidingscommissie-BMW Radboudumc, 2017-2023)
• Member of project monitoring board for Dutch government-funded project (ZonMw) on improvement of knowledge and knowledge infrastructure regarding drug use in pregnancy. (2013-2015)