Mass spectrometers for metabolomics

The Translational Metabolic Laboratory (TML) hosts an array of mass spectrometers for metabolomics in GC-MS and LC-MS setting. We have Maldi,- Triple-quadrupole- and Qtof mass spectrometers.

TML is specialized in metabolite analyses in body fluids of patients in the context of diagnostics of inborn errors of metabolism. Studies with stable isotope labeling are possible. Sensitivity limits of the mass spectrometry techniques are typically in the low micromolar range for triple-quadrupole analyses and in the low nanomolar range for the Qtof mass spectrometry.  

In addition, our laboratory has high field strength NMR spectrometer also suited for metabolomics purposes in complex matrices.
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Research Radboudumc Technology Centers Mass spectrometry Metabolomics

Mass spectrometers for metabolomics

The Translational Metabolic Laboratory (TML) hosts an array of mass spectrometers for metabolomics in GC-MS and LC-MS setting. We have Maldi,- Triple-quadrupole- and Qtof mass spectrometers. read more

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+31 (0)24 361 45 67

What is metabolomics?

Metabolomics techniques provide an overview of the metabolome, the small molecules that do the house-keeping in our cells and body. read more

What is metabolomics?

Metabolomics techniques provide an overview of the metabolome, the small molecules that do the house-keeping in our cells and body. Targeted metabolomics looks at specific subsets of small molecules. Untargeted metabolomics gives a more holistic overview of metabolites present in body fluids, culture media or cell homogenates.

Metabolomics applications

Examples of targeted metabolomics analyses of groups of metabolites are:
  • organic acids
  • sterols
  • monosaccharides
  • purines
  • pyrimidines
  • amino acids
  • nucleotide sugars

Melabolomics experts

see all our mass spectrometry experts

Other fields

Glycomics

We provide diagnostics for glycosylation and lysosomal disorders and aim to improve our methods using new state-of-the-art mass spectrometry.

Proteomics

We focus on mass spectrometry-based protein analyses and have proteomics expertise in a wide range of biological and analytical applications. read more

Radboudumc Technology Center Mass spectrometry

This technology center offers high-level expertise in bioanalytical mass spectrometry combined with in-depth knowledge on biomedical and clinical applications, embedded in a cutting-edge clinical and fundamental research environment.

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