Innate immunity in health and diseases

Research Research programs Innate immunity in health and diseases

Our purpose

We aim to understand the function and the regulation of innate immune system in health and disease, and to perform research towards development of diagnostic and therapeutic strategies targeting innate immunity.

Goals

See some of the most important goals for this research program.

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Goals

To study innate immune responses is at population level, through the integration of deep immunological phenotyping with various layers of omics: genomics, epigenomics, transcriptomics, metabolomics, proteomics.
To understand the innate immune-based mechanisms that contribute to the pathophysiology of diseases (infections, inflammatory diseases, such as atherosclerosis, gout, and cancer).
To improve efficacy of vaccines against several microorganisms using trained immunity.
To explore optimize the use of innate immune mechanisms (e.g. recombinant cytokines, trained immunity) for immunotherapy of cancer, infections and inflammatory diseases.

Research groups contributing to this research program

Experimental medical parasitology

Benjamin Mordmüller's research group discusses, develops and uses human challenge models to investigate infection, pathophysiology and transmission of infectious agents with the aim to improve medical interventions.

Genomic technologies for immune-mediated and infectious diseases

Alexander Hoischen's research group focuses on the application of the latest genomic technologies to understand human disease. A particular emphasis is put on the understanding of genetic defects that explain rare disease specifically immune diseases, such as inborn errors of immunity (IEIs).

Global health and infectious diseases

Reinout van Crevel's research group studies patients in Europe, Asia and Africa to understand pathogenesis and to improve clinical management.

Spokesperson

prof. dr. Leo Joosten

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