Goals

  • Identifying mechanisms of therapy resistance in model systems.
  • Exploiting molecular knowledge to overcoming therapy resistance in vitro, in preclinical models, in silico.
  • Clinically relevant improved targeting strategies and precision medicine.
  • Collective processes in tumor biology and immune defense.
  • In vivo registration and repurposing molecular reporters across tissue types and disease models.
  • Understanding and targeting fibrosis.
  • 3D models and  targeting of the myofiber compartment.
  • Reactive oxygen species-(ROS-) targeted therapies.


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Research Research programs 3D biology and disease mechanisms

Our purpose

We aim to identify mechanisms of therapy resistance in model systems.

Goals

See some of the most important goals for this research program.

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Research groups contributing to this research program

Computational immunology

Johannes Textor's research group studies the adaptive immune system, and its response to cancer, using computational tools such as simulations, machine learning algorithms, and artificial intelligence.

Experimental immunology

Annemiek van Spriel's research group studies the immune system at the cellular and molecular level. 

Immune dysregulation in hematologic malignancies

Willemijn Hobo's research group focuses on deciphering mechanisms underlying immune dysfunction in cancer patient and development of novel therapeutic approaches to (re)establish immune-mediated tumor control.

Spokesperson

prof. dr. Alessandra Cambi

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Spokesperson

prof. dr. Peter Friedl

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Spokesperson

prof. dr. Jack Schalken

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