Goals

  • Identifying mechanisms of therapy resistance in model systems.
  • Exploiting molecular knowledge to overcoming therapy resistance in vitro, in preclinical models, in silico.
  • Clinically relevant improved targeting strategies and precision medicine.
  • Collective processes in tumor biology and immune defense.
  • In vivo registration and repurposing molecular reporters across tissue types and disease models.
  • Understanding and targeting fibrosis.
  • 3D models and  targeting of the myofiber compartment.
  • Reactive oxygen species-(ROS-) targeted therapies.


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Research Research programs 3D biology and disease mechanisms

Our purpose

We aim to identify mechanisms of therapy resistance in model systems.

Goals

See some of the most important goals for this research program.

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Research groups contributing to this research program

Biochemistry of integrative systems

Roland Brock's research group focuses on the targeted delivery of nanomedicines including mRNA antisense oligonucleotides and therapeutic proteins making intensive use of microfluidic tissue-on-a-chip systems and microscopy.

Bone biochemistry

Nico Sommerdijk's research group investigates the mechanisms of collagen assembly and mineralization in health and disease, with focus on processes in bone formation and heart valve calcification.

Cancer pharmacology

Nielka van Erp's research group focuses on describing, explaining, understanding and modifying the pharmacokinetics of oral anticancer drugs.

Spokesperson

prof. dr. Alessandra Cambi

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Spokesperson

prof. dr. Peter Friedl

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Spokesperson

prof. dr. Jack Schalken

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