Mitochondrial molecular medicine

Research Research groups Mitochondrial molecular medicine

About

We study mitochondrial biochemistry, bridging classical bioenergetics and the central role of mitochondria in apoptosis, degenerative disorders and aging. We have established complexome profiling to study components of macromolecular assemblies.

Research group leader

prof. dr. Ulrich Brandt

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Publications

See some of our most important scientific articles.

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Publications

1. van Strien, J., Evers, F., Lutikurti, M., Berendsen, S.L., Garanto, A., van Gemert. G.J., Cabrera-Orefice, A., Rodenburg, R.J., Brandt, U., Kooij, T.W.A., Hujnen, M.A. (2023) Comparative Clustering (CompaCt) of eukaryote complexomes identifies novel interactions and sheds light on protein complex evolution. PLoS Computational Biology 19, e1011090.
2. Salscheider, S.L., Gerlich, S., Cabrera-Orefice, A., Peker, E., Rothemann, R.A., Murschall, L.M., Finger, Y., Szczepanowska, K., Ahmadi, Z. A., Guerrero-Castillo, S. Erdogan, A., Becker, M. Ali, M., Habich, M., Petrungaro, C., Burdina, N., Schwarz, G., Klußmann, M., Neundorf, I., Stroud, D.A., Ryan, M.T., Trifunovic, A., Brandt, U., Riemer, J. (2022) AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. EMBO Journal, 41, e110784.
3. Guerrero-Castillo, S., van Strien J., Brandt, U., Arnold, S. (2021) Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome. EMBO Journal, 40, e108648.
4. Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U (2018) Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps. Nature Communications 9: 4500.
5. Guerrero-Castillo S, Baertling F, Kownatzki D, Wessels HJ, Arnold S, Brandt U, Nijtmans L (2017) The assembly pathway of mitochondrial respiratory chain complex I. Cell Metabolism 25:128-139.
6. Huynen MA, Mühlmeister M, Gotthardt K, Guerrero-Castillo S, Brandt U (2016) Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. BBA – Mol Cell Res 1863:91-101.
7. Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U (2015) Mechanistic insight from the crystal structure of mitochondrial complex I. Science, 347:44-49.
8. Heide H, Bleier L, Steger M, Ackermann J, Dröse S, Schwamb B, Zörnig M, Reichert AS, Koch I, Wittig I, Brandt U (2012) Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly (MCIA) complex. Cell Metabolism 16:538-549.
9. Dröse S, Krack S, Sokolova L, Zwicker K, Barth HD, Morgner N, Heide N, Steger M, Nübel E, Zickermann V, Kerscher S, Brutschy B, Radermacher M, Brandt U (2011) Functional dissection of the proton pumping modules of mitochondrial complex I. PLoS Biology 9, e1001128.
10. Hunte C, Zickermann V, Brandt U (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. Science 329:448-451.
See the publication list on Web of Science.