Research group Mitochondrial molecular medicine

Publications

• A selection of our publications

  1. van Strien, J., Evers, F., Lutikurti, M., Berendsen, S.L., Garanto, A., van Gemert. G.J., Cabrera-Orefice, A., Rodenburg, R.J., Brandt, U., Kooij, T.W.A., Hujnen, M.A. (2023) Comparative Clustering (CompaCt) of eukaryote complexomes identifies novel interactions and sheds light on protein complex evolution. PLoS Computational Biology 19, e1011090.
  2. Salscheider, S.L., Gerlich, S., Cabrera-Orefice, A., Peker, E., Rothemann, R.A., Murschall, L.M., Finger, Y., Szczepanowska, K., Ahmadi, Z. A., Guerrero-Castillo, S. Erdogan, A., Becker, M. Ali, M., Habich, M., Petrungaro, C., Burdina, N., Schwarz, G., Klußmann, M., Neundorf, I., Stroud, D.A., Ryan, M.T., Trifunovic, A., Brandt, U., Riemer, J. (2022) AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. EMBO Journal, 41, e110784.
  3. Guerrero-Castillo, S., van Strien J., Brandt, U., Arnold, S. (2021) Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome. EMBO Journal, 40, e108648.
  4. Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U (2018) Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps. Nature Communications 9: 4500.
  5. Guerrero-Castillo S, Baertling F, Kownatzki D, Wessels HJ, Arnold S, Brandt U, Nijtmans L (2017) The assembly pathway of mitochondrial respiratory chain complex I. Cell Metabolism 25:128-139.
  6. Huynen MA, Mühlmeister M, Gotthardt K, Guerrero-Castillo S, Brandt U (2016) Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. BBA – Mol Cell Res 1863:91-101.
  7. Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U (2015) Mechanistic insight from the crystal structure of mitochondrial complex I. Science, 347:44-49.
  8. Heide H, Bleier L, Steger M, Ackermann J, Dröse S, Schwamb B, Zörnig M, Reichert AS, Koch I, Wittig I, Brandt U (2012) Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly (MCIA) complex. Cell Metabolism 16:538-549.
  9. Dröse S, Krack S, Sokolova L, Zwicker K, Barth HD, Morgner N, Heide N, Steger M, Nübel E, Zickermann V, Kerscher S, Brutschy B, Radermacher M, Brandt U (2011) Functional dissection of the proton pumping modules of mitochondrial complex I. PLoS Biology 9, e1001128.
  10. Hunte C, Zickermann V, Brandt U (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. Science 329:448-451.

• Publication list of the research group leader

  See the publication list on Web of Science.