Research group Biological and molecular imaging in experimental radiotherapy

Aims

In recent years, the emphasis has been on specific radioresistance mechanisms, in particular the prevention of short-term hypoxia. Changes in oxygenation were studied with biological (microscopic) and functional (nuclear tracers) techniques. With the scientific developments towards combinations with immunotherapy and the possibilities to expand this in our own laboratory, we are investing in optimizing the combination of radiotherapy immunotherapy.

The core of this research lies in 'reprogramming' the metabolism of tumors so that less oxygen is consumed over longer periods of time. This gives the immune system more 'grip' on tumor cells and makes the tumor cells more sensitive to radiotherapy.

In addition, clinical research is carried out in lung tumors and gynaecological malignancies, and this also involves a combination of biological and molecular imaging techniques. Within this research, functional and model-based research is carried out focusing on toxicity analysis and radiomics using AI techniques.

The central theme is to reverse radioresistance and to optimize the combination of immunotherapy and radiotherapy by reprogramming the tumor microenvironment. Crucial for introduction to the clinic is the selection and monitoring of this treatment through biological and molecular imaging.

Publications

• Publication list of the research group leader

  See the publication list on Web of Science.