NL
DE
About
We focus on the targeted delivery of nanomedicines including mRNA antisense oligonucleotides and therapeutic proteins making intensive use of microfluidic tissue-on-a-chip systems and microscopy.
Research group leader
prof. dr. Roland Brock
Aims
We aim at the development of targeted nanomedicines for disorders for which either no treatments are available, or the available medicines either lack efficiency or have too high side effects when applied systemically. Examples for the former are oligonucleotide-based therapies which critically depend on delivery strategies that mediate cellular entry, examples for the latter are bacterial toxins which kill cells at very low concentrations. For oligonucleotide delivery, we explore a broad range of approaches ranging from peptide-based approaches such as cell-penetrating peptides to retargeted viruses. For toxins, we focus on engineered proteins such as DARPins and nanobodies which are smaller than antibodies and therefore possess better tissue penetration. By using advanced microscopy techniques and innovative tissue/tumor-on-the-chip approaches we achieve a detailed understanding on the working mechanism in particular with respect to cell entry and tissue penetration. Based on these insights we identify the most promising molecular candidates for preclinical in vivo research. This research is very interdisciplinary involving expertise in chemical biology conjugation techniques, protein engineering, microfluidics, advanced fluorescence microscopy and molecular pharmacology. As part of the Radboudumc we engage in numerous collaborations with clinical research groups to provide innovative therapeutic strategies in a broad spectrum of disease areas. Moreover, we bridge even more fundamental research in chemistry and cell biology with the clinic.
Research programs
Programs that are connected to this research group.
