Facility Radiotherapy

About our equipment

With our SARRP we can irradiate tumors in animals with varying doses. Our Physicists and technicians will determine the settings of the equipment and after that treatment with a dose varying from almost zero to >50Gy is possible. During irradiation anesthesia can be applied with gas inhalation or other types of anesthesia. Hence tumors can be treated while the animals are breathing air, or oxygen enhanced gas mixtures.

With the equipment we can also treat cell cultures, cells etc. Again, the range of treatment doses is wide.

To plan your experiments we can help with discussions on the treatment dose that is optimal for your experiment. For experimental set up and agenda’s please contact Jasper Lok or Jan Bussink.

Applications in PRIME

The SARRP from Xstrahl is a self-contained X-ray system for delivering a precise radiation dosage to specimens in a biological or small animal research laboratory. The SARRP can deliver radiation CT guided. This allows to irradiation of small animals similar to the clinical situation. The X-ray tube is used specifically for radiation therapy having a highly homogenous beam. Our current setups can be used for:

• Cell irradiation (cell culture flasks, multi-well plates, chamber slides)
• Tumor irradiation of mice with a tumor at hind leg; fluoroscopy guided, high throughput)
• Orthotopic tumor irradiation; CT guided (low throughput)
• Total body irradiation (mice)