dr. Manoe Janssen PhD

About Manoe Janssen

Manoe Janssen completed the bachelor Molecular Life Sciences and the Master Molecular mechanisms of disease at Radboudumc. She did her PhD at the department of Gastroenterology and Hepatology on the molecular mechanisms underlying polycystic liver disease. Next she spend 2 years in Belgium at the stem Cell Institute in Leuven, after which she joined the lab of Prof Dr Roos Masereeuw at the department of Pharmaceutical Sciences in Utrecht. Here she became assistant professor specialized in genetic kidney disease research. For this she developed in vitro cell models of various genetic kidney diseases for therapy development and the evaluation of nephrotoxicity. She previously received funding from the Dutch kidney foundation and seed grant from cystinosis Ireland to determine the potential of CRISPR/Cas gene editing as a new therapy for Cystinosis.

In 2024 Manoe joined the preclinical team of the Radboudumc Therapy Accelerator for Rare Diseases. The goal of this team is to support ongoing and new research initiatives within Radboudumc and improve translation of new findings to the clinic. 

Personal prizes & awards

• IMAGEN: IMplementation of Advancements in GENetic Kidney Disease. (Health Holland 2020, 314 k€)
• Cut to cure, gene editing for cystinosis (Junior Kolff Nierstichting 2016, 200 k€)
• The holy grail of toxin removal (ZonMW Off-road 2018, 100 k€)
• Gene repair for cystinosis (Cystinosis Ireland 2019, 10 k€)
• Druggable Targets In Lysosomal V-ATPase Dysfunction (DETAILED) (Stofwisselkracht 2018, 25 k€)
• Drug screen with Pivot park screening centre (ZonMW ETH 2017, 30 k€)

Expertise

• Advanced in vitro models
• Genetic diseases
• Grant writing
• Gene therapy approaches
• CRISPR-cas9 based gene editing