prof. dr. Joost Hoenderop

About Joost Hoenderop

Joost Hoenderop is full professor of Molecular Kidney Physiology, has a background in molecular biology and obtained his Ph.D. degree in Medical Sciences at the Radboud University Nijmegen in 2000. Subsequently, he held an EMBO fellowship at the Institute of Pharmacology and Toxicology at the University of Lausanne, Switzerland.

Research interests include the regulation of Ca2+ and Mg2+ transport in epithelia with a specific focus on the molecular regulation of epithelial Ca2+ and Mg2+ channels (TRPV5&6 and TRPM6&7), members of the transient receptor potential (TRP) channels. Recent studies indicate that these channels function as gatekeepers to maintain the extracellular Ca2+ and Mg2+ balance which is crucial for mammalian development and function. His current work focuses on the functional aspects of these channels using a comprehensive approach that includes studies on epithelial cell lines and animal knockout models, identification of regulatory partners and electrophysiological analysis of channel activity.