NL
DE
With the advent of Direct Acting Antivirals, treatment of hepatitis C during pregnancy may come into reach. In a recent publication in American Journal of Obstetrics and Gynecology researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.
Jolien Freriksen and colleagues from RIMLS and RIHS studied the placental passage of daclatasvir and the main circulating metabolite of the drug sofosbuvir (GS-331007). In the laboratory-based study, fetal and maternal circulations of term human placentas were re-established immediately after birth. In this controlled setting, it was then studied how the placenta handled the drugs, ex vivo.
A main finding of the study was that GS-331007 and daclatasvir both cross the human placental barrier. This indicates that maternal use of sofosbuvir/daclatasvir may be beneficial in terms of fetal pre-exposure prophylaxis, but on the other hand could have adverse fetal effects. For a better and safer treatment of women living with HCV, future studies should now further chart the potential of Direct Acting Antivirals to improve maternal health and reduce the prevalence of pediatric hepatitis C.
-
Want to know more about these subjects? Click on the buttons below for more news.
Related news items
Grants for heart and kidney research Two awards to Radboudumc in Open Competition ENW-XS
21 July 2022Two researchers from the Radboudumc receive a grant from the NWO within the Open Competition of the Exact and Natural Sciences. They are Thijs Eijsvogels, who studies the heart, and Pieter Leermakers, who studies the kidneys.
read more
Technology saves lives! 1.9 million euros from the Heart Foundation for developing smart watches
17 November 2021 Niels van Royen is proud to be part of this consortium, initiated by Judith Bonnes, to develop a wrist band for early detection of cardiac arrest. Together with Erasmus, Reinier de Graaf and Corsano Health. read more
RIMLS awards call for nominations
19 October 2021 RIMLS awards several prizes to stimulate and honor our (young) researchers. Upcoming awards are Supervisor of the Year, Best Master Thesis, Best Publication, Best Image and more. Send your nominations now before 24 November 2021. read more
Turbo Grants for four medical-technical research projects
19 October 2021 Four TURBO grants were recently awarded to new technical-medical research proposals. The grants are part of the TURBO program, a collaboration between the University of Twente (TechMed Centre) and the Radboudumc. read more
Report of the 12th New Frontiers symposium Better care, network care? - 2 November 2018
7 November 2018 No easy answers at this symposium last Friday, only challenges that can be overcome if we succeed in 5 things. First and most radically, put patients in the center of healthcare. Second, start with assessing what the local population needs and not what local professionals have to offer. read more
