11 May 2020
In the Journal of Controlled Release, Fang Yang, theme Reconstructive and regenerative medicine, and colleagues, have designed and formulated a tunable and injectable local delivery system by loading the PLGA-drug microspheres into the PIC hydrogel. This system exhibited appropriate injectability, long-term structural stability, and no obvious in vivo inflammatory response. Furthermore, the release of drugs could be controlled by adjusting the loaded mass ratio of acid- and ester- end capped PLGA microspheres.
As evidenced in these results, they envision that upon further optimization, this novel and simple thermo-responsive PLGA-PIC carrier system may have the potential to be translated as an effective therapy for penalized medicine in periodontal clinics.
In the Journal of Controlled Release, Fang Yang, theme Reconstructive and regenerative medicine, and colleagues, have designed and formulated a tunable and injectable local delivery system by loading the PLGA-drug microspheres into the PIC hydrogel. This system exhibited appropriate injectability, long-term structural stability, and no obvious in vivo inflammatory response. Furthermore, the release of drugs could be controlled by adjusting the loaded mass ratio of acid- and ester- end capped PLGA microspheres.
As evidenced in these results, they envision that upon further optimization, this novel and simple thermo-responsive PLGA-PIC carrier system may have the potential to be translated as an effective therapy for penalized medicine in periodontal clinics.
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