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11 January 2019
Furthermore, they showed that NOX-dependent and NOX-independent NETs differ in their endothelial cell stimulatory capacity. These results indicate heterogeneity in NET-forming pathways in vivo and highlight the need for disease-specific strategies to prevent NET-mediated pathology.Their findings were recently published in Annals of the Rheumatic Diseases, the highest ranking journal in the field of Rheumatology.
Neutrophils can produce Neutrophil Extracellular Traps (NETs), which are web-like structures consisting of chromatin aimed to capture pathogens. NETs appear to play a role in several diseases including rheumatic autoimmune diseases. Although NET formation was originally described as a NADPH oxidase (NOX)-dependent pathway, it appears that there are also NOX-independent pathways of NET release. Currently, no tools are available that can discriminate between different NET-forming pathways.
Furthermore, they showed that NOX-dependent and NOX-independent NETs differ in their endothelial cell stimulatory capacity. These results indicate heterogeneity in NET-forming pathways in vivo and highlight the need for disease-specific strategies to prevent NET-mediated pathology.Their findings were recently published in Annals of the Rheumatic Diseases, the highest ranking journal in the field of Rheumatology.
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