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Researchers of the Radboudumc and colleagues, have successfully developed enzyme-loaded polymersomal nanoreactors capable of undergoing cellular integration in a controlled fashion and, subsequently, function as synthetic organelles. They published their findings in ACS Central Science.
For the first time, patient-derived complex I-deficient primary skin fibroblasts are effectively protected against the toxicity of exogenous hydrogen peroxide by the action of internalized catalase-loaded nanoreactors, showcasing this system in a therapeutically relevant context.
The work was performed by PhD candidate Lisanne van Oppen and co-workers in the laboratories of Biochemistry and Pediatrics, theme Mitochondrial diseases, of the Radboudumc and assistant professor Loai Abdelmohsen and co-workers in the research group of Bio-Organic Chemistry at the Eindhoven University of Technology.
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