NL
DE
Osteoarthritis is the most prevalent and debilitating joint disease worldwide but no cure has been developed yet. Recent findings show that low grade inflammation within the OA joint may contribute to the pathophysiology and clinical symptoms.
Arjen Blom and Martijn van den Bosch, theme Inflammatory diseases will focus on the involvement of the Wnt-signaling induced protein WISP1 in cartilage destruction in osteoarthritis (OA). The sequence of events that leads to cartilage destruction via WISP1 will be studied both in experimental OA and in a human trial.
Peter van Lent, theme Inflammatory diseases will focus on the therapeutic efficacy of PCSK9 inhibitors in dampening cholesterol driven synovial inflammation and joint destruction in OA. The group of Peter van Lent has significantly contributed in understanding the role of inflammation and joint destruction in osteoarthritis.
Arjen Blom Martijn van den Bosch Peter van Lent
-
Want to know more about these subjects? Click on the buttons below for more news.
Related news items
Joyce Aarts and colleagues published in Scientific Reports about the role of TGF-β1 in (experimental) arthritis
30 March 2022 Joyce Aarts, theme Inflammatory diseases, and her colleagues published in Scientific Reports, that local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis. read more
Large NWA ORC grant awarded for national skin research: Next Generation ImmunoDermatology
23 March 2022 Research for better treatment methods for chronic skin diseases. read more
OARSI Basic Science Award for Peter van der Kraan
22 May 2020 Purpose of this Basic Science Award of the Osteoarthritis Research Society International (OARSI) is to stimulate fundamental research in the field of osteoarthritis. Congratulations Peter. read more
PPP allowance by Health~Holland for Fons van de Loo
16 December 2019 Fons van de Loo, theme Inflammatory diseases, has been granted a 3 year PPP Allowance made available by Health~Holland for the project ‘REFIT’. The goal of this project is to restore the barrier function, immunity and microbiome of the intestinal tract using extracellular vesicles from milk. read more
Four Veni grants for junior RIMLS researchers
22 July 2019 Four junior researchers, affiliated to the RIMLS, have each received a Veni grant of 250,000 Euro from NWO. Our researchers received this prestigious grant for their remarkable and original talent and their ability to carry out innovative research. read more
