Peter van der Kraan, theme Inflammatory diseases has obtained a research grant from European League against Rheumatism (EULAR) of Euro 600.000. The project "SEN-OA - Targeting senescent cells in osteoarthritis: an innovative therapeutic approach" has been granted by FOREUM (Foundation for Research in Rheumatology, EULAR).
This endeavor is a cooperation between research groups in France, Spain and Nijmegen. Increasing evidence suggests that many chronic diseases such as osteoarthritis (OA) are associated with hallmarks of ageing, including epigenetic alterations, mitochondrial dysfunction, cellular senescence, altered autophagy and intercellular communication that could promote disease onset. One emerging therapeutic approach for ageing-associated diseases would be to specifically deplete senescent cells to prevent the detrimental secretion of senescence-associated secretory phenotype (SASP) products.EULAR: link
FOREUM: link
-
Want to know more about these subjects? Click on the buttons below for more news.
Related news items
Joyce Aarts and colleagues published in Scientific Reports about the role of TGF-β1 in (experimental) arthritis
30 March 2022Joyce Aarts, theme Inflammatory diseases, and her colleagues published in Scientific Reports, that local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis.
read moreLarge NWA ORC grant awarded for national skin research: Next Generation ImmunoDermatology
23 March 2022Research for better treatment methods for chronic skin diseases.
read more