News items Major European grant

23 February 2018

A European consortium led by Radboud university medical center has been awarded a European grant worth € 26 million for research into hypoglycemia. To curb the health risks and burden of disease caused by the ‘hypo’ (as it is known), in-depth research will be carried out by knowledge institutions, patient organizations and partners from industry.

Diabetes is the most common chronic disease in the world. Europe alone has around 60 million patients, 10% of whom have type 1 diabetes. People with diabetes are unable to regulate the level of glucose in their blood automatically and use insulin to reduce high glucose (or sugar) levels. This is a very precise process. One of the side-effects of using insulin is developing a low concentration of glucose in the blood. This is known as hypoglycemia, or ‘hypo’ for short. 

Important obstacle

Hypoglycemia is a serious side-effect that can cause symptoms such as confusion, cognitive problems and loss of consciousness. For this reason, patients and their families dread ‘hypos’. Hypoglycemia not only affects the patient’s quality of life, it also increases the risk of cardiovascular disease. Hypoglycemia is therefore an important obstacle when it comes to effective treatment for diabetes. 

European grant

The Hypo-RESOLVE consortium, headed by doctors of internal medicine Bastiaan de Galan and Cees Tack, theme Mitochrondrial diseases, was recently awarded a grant worth € 26 million by the European Commission. The funding is for research designed to reduce the disease burden and consequences of hypoglycemia. The research project Hypo-RESOLVE (Hypoglycemia – Redefining SOLutions for better liVEs) was allocated a grant within the framework of the EU Horizon 2020-IMI program. 

Understanding the hypo

Bastiaan de Galan: “We want to formulate the answers to questions that still go unanswered almost one hundred years after the discovery of insulin. One of our methods will be to set up a mega-database in which we combine 100 to 150 insulin trials to ascertain exactly how often hypoglycemia occurs. This will help us to define hypoglycemia and identify predictors in various populations. We can then use this information to derive practical standards and recommendations for pharmaceutical authorities, patient organizations and future research among patients.” 

Better treatment

Cees Tack: “We also intend to carry out fundamental and applied research to study and clarify the underlying mechanisms involved in hypoglycemia. This knowledge will enable us to develop new treatments for patients who don’t feel the warning signs of impending hypoglycemia. In addition, we will try to discover whether continuous glucose monitoring using a glucose sensor is worthwhile in practice. You mustn’t underestimate the psychological and economic impact of hypoglycemia on patients and their families. We want to define the extent of this impact as objectively as possible.”
The consortium hopes that this broad-based approach will ultimately achieve better quality of life for patients with diabetes who are treated with insulin.

More information


Pieter Lomans

persvoorlichter

Related news items


Newborn screening in sight through the discovery of novel disease biomarkers by new technique

8 July 2021 To identify new biomarkers that can be used in the newborn screening protocol, also known as the neonatal heel prick, Karlien Coene and colleagues joined forces with scientists at the Radboud University’s FELIX laser laboratory. They published their findings in The Journal of Clinical Investigation. read more

First volunteers vaccinated with Radboudumc malaria vaccine

20 May 2021 Today a new vaccine against malaria, largely developed in Nijmegen, is being tested for the first time in volunteers at Radboudumc. read more

New way of diagnostics detects 'undetectable' genetic defects

15 April 2021

Research provides guidance for global application

read more

New insight into the effect of hydroxychloroquine undermines its use in corona

11 June 2020 Researchers at Radboud university medical center have discovered an as yet unknown effect of hydroxychloroquine. Raphael Duivenvoorden was interviewed in the program Op1 at NPO1 to elaborate on the findings. It seems unlikely that chloroquine has beneficial effect in corona infections. read more

Newly appointed Junior Principal Clinicians

3 December 2019 The appointed junior Principal Clinician for RIMLS are Heidi Zweers-van Essen and Jenneke Leentjens. These caregivers are at the forefront of renewing patient care and take the lead in the development and realization of the Radboudumc vision. read more

Dr. C.J. Roos prize for Hanne Rooijackers

9 May 2019 Hanne Rooijackers, theme Mitochondrial diseases, has been awarded the Dr. C.J. Roos prize for her thesis 'Impaired awareness of hypoglycaemia in type 1 diabetes. The role of lactate.' read more